ABSTRACT
Objectives: The purpose of this study was to evaluate the laboratory measurements and thorax computed tomography (CT) findings of pregnant women with COVID-19. Methods: This was a single-center, observational study performed in a Training and Research Hospital from March 1 to May 31, 2020. Laboratory data, clinical conditions, and thorax CT images of pregnant women with COVID-19 were analyzed retrospectively. The patients who agreed to the image and were not suspected of pneumonia were classified according to their degree of lung involvement. Results: A total of 155 pregnant women have included in the study, and the thorax CT of 86 (55.5%) pregnant women who participated in the study was evaluated. While no symptoms were observed in 44 (28.4%) of the pregnant women, the most common symptoms were dyspnea and cough in 27 (17.4%). Of the pregnant women evaluated for thorax CT, 24 (27.9%) had negative, 19 (21.1%) had mild involvement, 30 (34.9%) had moderate involvement, and 13 (15.1%) had heavy involvement. C-reactive protein (CRP) levels of pregnant women with negative tomography were 4.5 (0.7–83.4) mg/L, 13.4 (0.7–107.3) mg/L with mild involvement, 37.7 (3.8–292.6) mg/L with moderate involvement and, 48.6 (5.7–234.1) mg/L with heavy involvement (p<0.001). Conclusion: All factors affecting the prognosis for pregnant women with COVID-19 have not been fully elucidated. It was determined that a significant frequency of pregnant women was asymptomatic. In addition, an increase was observed in the CRP level according to the severity of pneumonia, while no similar difference was found in the D-dimer level. ©Copyright 2023 by Anatolian Journal of Family Medicine.
ABSTRACT
Objective: Deficiencies in immune-regulatory mechanisms such as immune activation and T-regulatory cells are classically referred to as cytokine storms. Mesenchymal stem cells (MSCs) act as living anti-inflammatory cells that can rebalance cytokine/immune responses to restore balance in patients with coronavirus disease-2019 (COVID-19) acute respiratory distress syndrome by reducing the activation of T and B cells, and dendritic and natural killer cells. The aim of this study is to provide immune modulation with stem cell transplantation by reducing the damage caused and COVID-19 infection to tissues and organs. Material and Methods: In this prospective randomized single-center clinical trial, patients were divided into 3 groups: intubated without comorbidity (n = 7);intubated with comorbidity (n = 7);not intubated (n = 7). Dosage of MSCs transplantation for each group was 1 million cell/kg intravenous at days 0, 2, and 4. age, gender, APACHE II scores, procalcitonin, C-reactive protein (CRP) and leukocyte values, and cluster of difference 4 (CD4), CD8, interleukin 2 (IL-2), and IL-6 levels, morbidities, number of days in intensive care unit, mortality were recorded. Clinical results, changes in inflammatory and immune function levels, and side effects were evaluated. Each patient's improvement in oxygenation and symptoms were recorded in the days after MSC transplantation. After treatment, lymphocyte, CRP, tumor necrosis factor-a level, and IL-6 levels were recorded.
ABSTRACT
In late 2019 on 11th March 2020 a novel coronavirus, SARS-CoV-2 causing Coronavirus disease 2019 (COVID-19) appeared in Wuhan, China and World Health Organisation declared it to have developed pandemic status. Although there are many detection techniques for the diseaseto control the pandemic such as RT-PCR, serological methods, or fast antigen tests, the actual problem is the prevention of the disease. The nasal cavity and rhino pharynx are key sites of the initial replication of SARS-CoV-2.In this article, the effectiveness of destrovir spray was investigated by creating a mechanical barrier in the nasal and oral mucosa, which are the entry points of the virus into the body, and to destroy the virus that comes into contact with this barrier. In the presented study, quantitation cycle (Cq) and irradiation values (RFU) of 12 different high-positive patients (Cq <= 25) after application of both RT-PCR and destrovir spray were determined at different concentrations (10%, 20%, 30%, 40%, and 50%) aimed to evaluate its effectiveness. According to the results obtained by comparing the effectiveness of disinfectant with 70% ethyl alcohol on the 46 patient samples with Cq<20, 46 patient samples with Cq values between 20-25, and 46 patient samples with Cq >= 25 including different variants are examined. A total of 138 COVID-19 patient samples were treated with 5% and 10% ratios of destrovir spray. Its effectiveness on Cq values and RFU was evaluated and it was aimed to compare the effectiveness of this evaluation with 96% ethyl alcohol used in the same samples.